Breast tumor stiffness instructs bone metastasis via mechanical memory
A. W. Watson, A. Grant, S. S. Parker, M. W. Harman, M. R. Roman, B. L. Forte, C. C. Gowan, R. Castro-Portuguez, C. Franck, D. Cusanovich, M. Padi, C. Romanoski, G. Mouneimne
This study shows that primary tumor stiffness induces stable mechanical memory in breast cancer cells, promoting bone metastasis through ERK-RUNX2 signaling and a MeCo score.
bioRxiv · Nov 20, 2019 · PreprintCancer Biology