Chronic Aryl Hydrocarbon Receptor Activity Phenocopies Smoking-induced Skeletal Muscle Impairment
T. Thome, K. Miguez, A. Willms, L. Fitzgerald, S. S. Burke, V. Chandran, A. R. de Souza, C. Baglole, M.-E. Anagnostou, J. Bourbeau, R. T. Jagoe, J. A. Morais, Y. Goddard, T. Taivassalo, T. E. Ryan, R. T. Hepple
This study shows chronic AHR activation, like from smoking, causes muscle atrophy, mitochondrial issues, and neuromuscular junction damage in mice and humans.
bioRxiv · May 5, 2021Physiology