Author

T. Thome

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Approach:experimental assay· 4 Assay:bulk RNA-seq· 3 Organism:mouse· 3 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Research Focus:host-pathogen & immune response· 2 Research Focus:metabolism & bioenergetics· 2 Assay:ATAC-seq· 1

Frequent Co-Authors

T. E. Ryan· 4 shared C. Moparthy· 2 shared K. Kim· 2 shared L. F. Ferreira· 2 shared A. Murillo· 1 shared A. R. de Souza· 1 shared A. Willms· 1 shared C. Baglole· 1 shared

Activity by Year

2021-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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4 shared papersPhysiology

T. E. Ryan

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Author profile →

4 papers

Recent·Most cited

Chronic activation of the aryl hydrocarbon receptor in muscle exacerbates ischemic pathology in chronic kidney disease

N. Balestrieri, V. Palzkill, C. G. Pass, J. Tan, Z. R. Salyers, C. Moparthy, A. Murillo, K. Kim, T. Thome, Q. Yang, K. O'Malley, S. A. Berceli, F. Yue, S. T. Scali, L. F. Ferreira, T. E. Ryan

This study shows chronic AHR activation in muscle worsens ischemic damage in CKD and PAD by impairing muscle function and mitochondrial health.

bioRxiv · May 16, 2023Physiology

IGF-1 therapy improves muscle size and function in experimental peripheral arterial disease

G. Dong, C. Moparthy, T. Thome, K. Kim, T. E. Ryan

This study shows that IGF-1 therapy increases muscle size and strength in a rodent PAD model, with greater effects in female mice.

bioRxiv · Jul 31, 2022Physiology

Reversible thiol oxidation increases mitochondrial electron transport complex enzyme activity but not respiration in cardiomyocytes from patients with end-stage heart failure

R. A. Kumar, T. Thome, O. Sharaf, T. E. Ryan, G. Arnaoutakis, E. I. Jeng, L. F. Ferreira

bioRxiv · May 27, 2022Physiology

Chronic Aryl Hydrocarbon Receptor Activity Phenocopies Smoking-induced Skeletal Muscle Impairment

T. Thome, K. Miguez, A. Willms, L. Fitzgerald, S. S. Burke, V. Chandran, A. R. de Souza, C. Baglole, M.-E. Anagnostou, J. Bourbeau, R. T. Jagoe, J. A. Morais, Y. Goddard, T. Taivassalo, T. E. Ryan, R. T. Hepple

This study shows chronic AHR activation, like from smoking, causes muscle atrophy, mitochondrial issues, and neuromuscular junction damage in mice and humans.

bioRxiv · May 5, 2021Physiology