Evolutionary BiologybioRxivPreprint
Evolutionary models predict potential mechanisms of escape from mutational meltdown
C. Bank, M. A. Schmitz, A. Y. Morales-Arce
The paper uses computational models to explore how RNA viruses might escape mutagenic drugs by adapting through three mechanisms: beneficial mutations, mutation rate reduction, and fitness effect modification.
DOI 10.1101/2022.06.21.496937