C. Bank

Adaptation of human cell populations to different levels of centriole amplification

This study examines how human cell populations adapt to different levels of centriole amplification through long-term experimental evolution and fitness analysis.

Challenges and pitfalls of inferring microbial growth rates from lab cultures

This study identifies challenges in estimating microbial growth rates from lab cultures and shows that inaccurate estimates affect relative fitness calculations.

Unpredictability of the fitness effects of antimicrobial resistance mutations across environments in Escherichia coli

This study shows that the fitness effects of antimicrobial resistance mutations vary widely across genetic backgrounds and environments in Escherichia coli, challenging assumptions about their predictability.

Ecological tradeoffs lead to complex evolutionary trajectories and sustained diversity on dynamic fitness landscapes

This study simulates eco-evolutionary dynamics on a dynamic fitness landscape incorporating ecological interactions, showing that ecological interactions can sustain diversity and coexistence of genotypes.

STUN: forward-time Simulation on TUnable fitNess landscapes in recombining populations

STUN simulates polygenic adaptation in recombining populations using fitness landscape models and provides a flexible tool for studying evolutionary dynamics.

In search of the Goldilocks zone for hybrid speciation II: hard times for hybrid speciation?

The paper models how population size, linkage architecture, and incompatibility strength affect hybrid speciation and extinction risk in hybrid populations.

Rapid adaptation of recombining populations on tunable fitness landscapes

This study simulates adaptation in recombining populations on tunable fitness landscapes, finding that recombination hinders movement through rugged landscapes and that epistasis and recombination interact to influence allele fixation.

Solving the stochastic dynamics of population growth

The paper compares deterministic and stochastic models of population growth, showing deterministic models overestimate population sizes and introduces two novel solutions for stochastic dynamics.

Evolutionary rescue in a fluctuating environment

This study models evolutionary rescue in fluctuating environments, finding that stochastic fluctuations and shorter environmental cycles increase rescue likelihood, while larger populations and higher growth rates improve survival chances.

Epistasis decreases with increasing antibiotic pressure but not temperature

The paper quantifies genotype-by-genotype-by-environment interactions in E. coli under varying antibiotic and temperature conditions, finding that epistasis decreases with higher antibiotic pressure but not temperature.

Metagenomics and metabarcoding experimental choices and their impact on microbial community characterization in freshwater recirculating aquaculture systems

The paper compares metagenomics and metabarcoding methods in RAS systems, showing they provide complementary insights into microbial communities.

Evolutionary models predict potential mechanisms of escape from mutational meltdown

The paper uses computational models to explore how RNA viruses might escape mutagenic drugs by adapting through three mechanisms: beneficial mutations, mutation rate reduction, and fitness effect modification.

The extinction time under mutational meltdown

The paper calculates the extinction time of a population under high mutation rates using analytical methods and simulations, finding that deleterious mutation rate most strongly affects extinction time.

Imbalanced segregation of recombinant haplotypes in hybrid populations reveals inter- and intrachromosomal Dobzhansky-Muller incompatibilities

The paper develops new statistics to detect Dobzhansky-Muller incompatibilities in hybrid populations by analyzing haplotype frequency imbalances, identifying new DMI candidates in swordtail fish.

Epigenetic switching outcompetes genetic mutations during adaptation to fluctuating environments

This study shows that epigenetic switching provides a fitness advantage over genetic mutations in fluctuating environments, with coexistence possible under constant pressure at high switching rates.

Deleterious Mutation Accumulation and the Long-Term Fate of Chromosomal Inversions

This study uses simulations to show that recessive deleterious mutations accumulate in chromosomal inversions, leading to fitness decline and non-adaptive divergence, but can be halted by haplotype branching.

The adaptive potential of the middle domain of yeast Hsp90

The paper quantifies how adaptation costs vary across environments by analyzing mutations in the middle domain of yeast Hsp90, finding low adaptation cost and identifying regions enriched in beneficial or deleterious mutations.

The limits to parapatric speciation 3: Evolution of strong reproductive isolation in presence of gene flow despite limited ecological differentiation.

The paper investigates how strong reproductive isolation can evolve with gene flow and limited ecological differentiation using models of local adaptation and Dobzhansky-Muller incompatibilities.

Patterns of selection against centrosome amplification in human cell lines

The paper infers patterns of centriole overproduction and selection in human cell lines using mutation-selection-like models and finds strong uniform selection against extra centrioles.

Comprehensive fitness maps of Hsp90 show widespread environmental dependence

This study maps the fitness effects of Hsp90 variants across multiple environments, showing widespread environmental dependence and selection for robustness.

Low Mutational Load Allows for High Mutation Rate Variation in Gut Commensal Bacteria

The paper tracks long-term evolution of gut commensal E. coli in mice, finding high mutation rate variation and identifying molecular causes of hypermutator emergence and coexistence.

The fitness landscape of the codon space across environments

The paper quantifies the fitness effects of synonymous mutations across environments in yeast using Bayesian methods and shows their impact on evolutionary dynamics.

In search of the Goldilocks zone for hybrid speciation

This paper investigates the conditions under which hybrid speciation can occur through reciprocal sorting of genetic incompatibilities, identifying a 'Goldilocks zone' for specific linkage architectures and recombination rates.

Conflict between heterozygote advantage and hybrid incompatibility in haplodiploids (and sex chromosomes)

The paper models hybrid incompatibility and heterozygote advantage in haplodiploid species, showing how these factors lead to sexual conflict and different population outcomes.