Cytoplasmic labile iron accumulates in aging stem cells perturbing a key rheostat for identity control
Y.-R. Kao, J. Chen, R. Kumari, M. Tatiparthy, Y. Ma, M. Aivalioti, A. Zintiridou, V. Thiruthuvanathan, J. Reisz, S. Stransky, S. Sidoli, U. Steidl, A. D'Alessandro, B. Will
This study shows that aging stem cells accumulate labile iron, disrupting a key regulatory pathway that maintains their identity and function.
bioRxiv · Aug 3, 2021 · PreprintCell Biology