R. Kumari

VCD-induced menopause mouse model reveals reprogramming of hepatic metabolism

This study uses a VCD-induced menopause mouse model to show that ovarian loss disrupts hepatic mitochondrial function and lipid homeostasis, increasing susceptibility to diet-induced obesity and steatosis.

Mitochondrial dsRNA from B-ALL cells stimulates mesenchymal stromal cells to become cancer associated fibroblasts

This study shows that mitochondrial dsRNA from B-ALL cells triggers MSC to become CAFs, linking genetic subtypes to survival outcomes.

Musashi-2 causes cardiac hypertrophy and heart failure by inducing mitochondrial dysfunction through destabilizing Cluh and Smyd1 mRNA

This study shows that Msi2 induces cardiac hypertrophy and heart failure by causing mitochondrial dysfunction through destabilizing Cluh and Smyd1 mRNA.

Specialized actin nanoscale layers control focal adhesion turnover

The paper identifies two new nanoscale actin layers in focal adhesions, showing their distinct roles in adhesion maturation and disassembly through Tpm1.6 and Tpm3.2.

ATF5 is a regulator of exercise-induced mitochondrial quality control in skeletal muscle

This study investigates the role of ATF5 in mitochondrial quality control in skeletal muscle during rest and after acute exercise, finding that ATF5 deficiency leads to impaired mitochondrial function and altered stress responses.

Cytoplasmic labile iron accumulates in aging stem cells perturbing a key rheostat for identity control

This study shows that aging stem cells accumulate labile iron, disrupting a key regulatory pathway that maintains their identity and function.

Mast cells are mediators of fibrosis and effector cell recruitment in dermal chronic graft-versus-host disease

This study shows mast cells contribute to fibrosis and effector cell recruitment in dermal chronic GVHD, suggesting they are potential therapeutic targets.