Author

A.-L. Tsai

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 2 Research Focus:cell signaling & trafficking· 1 Assay:protein structure· 1 Research Focus:protein structure prediction· 1 Assay:structural biology· 1

Frequent Co-Authors

G. Wu· 3 shared J. Shen· 3 shared M. Zhou· 3 shared B. S. Pierce· 1 shared K. Chen· 1 shared L. Wang· 1 shared

Activity by Year

2021-2023 · peak 2/yr

Co-Author Collaboration Network

6 top collaborators · 13 mutual co-author links

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3 shared papersBiochemistry

G. Wu

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3 papers

Recent·Most cited

Free ferrous ions sustain activity of mammalian stearoyl-CoA desaturase-1

J. Shen, G. Wu, B. S. Pierce, A.-L. Tsai, M. Zhou

This study shows free ferrous ions sustain SCD1 activity by replenishing the diiron center during catalysis, revealing dynamic structural changes and a regulatory role for labile Fe2+ in lipid metabolism.

bioRxiv · Mar 17, 2023Biochemistry

Mechanism of stepwise electron transfer in six-transmembrane epithelial antigen of the prostate (STEAP) 1 and 2

K. Chen, L. Wang, J. Shen, A.-l. Tsai, M. Zhou, G. Wu

This study shows STEAP1 can support a cross-membrane electron transfer chain via FAD, and determines the structure of STEAP2 in complex with NADP+ and FAD.

bioRxiv · Dec 23, 2021Biochemistry

Transmembrane helices mediate the formation of a stable ternary complex of cyt b5 reductase, cyt b5, and SCD1

J. Shen, G. Wu, A.-L. Tsai, M. Zhou

This study shows that cyt b5 reductase, cyt b5, and SCD1 form a stable ternary complex mediated by transmembrane helices, enhancing electron transfer rates.

bioRxiv · Nov 13, 2021 · PreprintBiochemistry