The CUL4-DDB1-DCAF1 E3 ubiquitin ligase complex regulates PLK4 protein levels to prevent premature centriole duplication
J. Grossmann, A.-S. Kratz, A. Kordonsky, G. Prag, I. Hoffmann
The paper shows that the CUL4-DDB1-DCAF1 E3 ligase complex targets PLK4 for degradation in G2 phase to prevent premature centriole duplication.
bioRxiv · Sep 13, 2023 · PreprintCell Biology