Kappa Opioid Receptors in Mesolimbic Terminals Mediate Escalation of Cocaine Consumption
Lydia Gordon-Fennell, Ryan D. Farero, Lauren M. Burgeno, N.L. Murray, A.D. Abraham, Marta E. Soden, Garret D. Stuber, Charles Chavkin, Larry S. Zweifel, Paul E. M. Phillips
This study shows that KOR on VTA neurons, not NAcC neurons, prevents cocaine escalation by blocking the transition to SUD-like behavior.
bioRxiv · Dec 21, 2023 · PreprintNeuroscience