Charles Chavkin

This study identifies nalfurafine and nalmefene as agents that cause long-lasting KOR inactivation, potentially offering new therapeutic approaches for stress-related disorders.

This paper develops a fast, sensitive genetically encoded H2O2 sensor (oROS-G) and demonstrates its use in monitoring H2O2 dynamics in various cell types and models.

This study shows that KOR on VTA neurons, not NAcC neurons, prevents cocaine escalation by blocking the transition to SUD-like behavior.

The paper investigates how stress affects serotonin signaling in the nucleus accumbens through dynorphin and KOR pathways, influencing cocaine preference and aversion.

This study shows that dynorphin release in the prefrontal cortex during opioid withdrawal disrupts cognition, and KOR antagonism can block these effects.