L-type voltage-gated calcium channel agonists improve hearing loss and modify ribbon synapse morphology in the zebrafish model of Usher Syndrome Type 1
Alaa Koleilat, Joseph A. Dugdale, Trace A. Christenson, Jeffrey L. Bellah, Aaron M. Lambert, Mark A. Masino, Stephen Carl Ekker, Lisa A. Schimmenti
The paper identifies differences in hair cell biology and behavior in zebrafish myo7aa-/- mutants and shows that L-type voltage-gated calcium channel agonists can rescue these phenotypes.
bioRxiv · Dec 16, 2019 · PreprintNeuroscience