The N-terminal and central domains of CoV-2 nsp1 play key functional roles in suppression of cellular gene expression and preservation of viral gene expression
Aaron S. Mendez, Michael Ly, Angélica M. González-Sánchez, Ella Hartenian, Nicholas T. Ingolia, Jamie H. D. Cate, Britt A. Glaunsinger
This study identifies key residues in SARS-CoV-2 nsp1 that regulate host and viral mRNA translation, revealing functional differences between these mRNA types.
Cell Reports · Sep 30, 2021Peer-reviewedMolecular Biology