Ella Hartenian

NINJ1 is a restriction factor for HSV-1 in mouse macrophages

This study shows that NINJ1 restricts HSV-1 entry in mouse macrophages, reducing viral infection and associated inflammation.

Membrane Tension Drives Opening of NINJ1 Lesions in Dying Cells

This study shows membrane tension drives NINJ1 filament opening, causing cell lysis, and explains why NINJ2 fails to form lesions.

The N-terminal and central domains of CoV-2 nsp1 play key functional roles in suppression of cellular gene expression and preservation of viral gene expression

This study identifies key residues in SARS-CoV-2 nsp1 that regulate host and viral mRNA translation, revealing functional differences between these mRNA types.

Cytoplasmic mRNA decay represses RNA polymerase II transcription during early apoptosis

The paper shows that mRNA decay during early apoptosis represses RNA polymerase II transcription, creating positive feedback that amplifies gene expression shutdown.

Changes in mRNA abundance drive differential shuttling of RNA binding proteins, linking cytoplasmic RNA degradation to transcription

The paper shows that changes in mRNA decay alter RNA binding protein localization, linking cytoplasmic RNA degradation to transcription.