Antigen-specific T cell immunotherapy by in vivo mRNA delivery
Fang‐Yi Su, Jamison C. Siebart, Ching Shen Chan, Matthew Y. Wang, Xinyi Yao, Aaron Silva Trenkle, Avanti Sivakumar, Melanie Su, Rustin Harandi, Neha Shahrawat, Chi H. Nguyen, Anshika Goenka, Jinhee Mun, Madhav V. Dhodapkar, Gabriel A. Kwong
This paper develops antigen-presenting nanoparticles (APNs) for in vivo mRNA delivery to engineer Ag-specific T cells, showing efficacy in mouse models of type 1 diabetes and multiple myeloma.
bioRxiv · Oct 29, 2024 · PreprintBioengineering