Rapid enrichment of progenitor exhausted neoantigen-specific CD8 T cells from peripheral blood
Mamduh Khateb, Raina Jung, Stav Leibou, Patrick Hadley, Zhiya Yu, Aaron J Dinerman, Victoria Dulemba, Billel Gasmi, Noam Levin, Peter Kim, Aarushi Bhasin, Deepali Bhat, Sivasish Sindiri, Jared J. Gartner, Todd D. Prickett, , Nicholas D. Klemen
This paper describes a method to rapidly enrich neoantigen-specific CD8 T cells from peripheral blood, achieving frequencies comparable to tumor-infiltrating lymphocytes over 28 days.
bioRxiv · May 11, 2025 · PreprintImmunology