Author

Nicholas D. Klemen

Duke UniversityORCID 0000-0003-1353-539XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Research Focus:clustering· 2 Approach:experimental assay· 2 Organism:human· 2

Frequent Co-Authors

Aaron J DinermaniD· 1 shared Aarushi Bhasin· 1 shared Billel GasmiiD· 1 shared Daniel W. McVicariD· 1 shared David B. ThompsoniD· 1 shared Deepali Bhat· 1 shared Denitsa MilanovaiD· 1 shared Frank J. LoweryiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperImmunology

Aaron J DinermanORCID

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2 papers

Recent·Most cited

ImmunologybioRxivPreprintJun 3, 2026

From prediction to engagement: defining tumor-reactive T cells through biological interaction

Nicholas P. Restifo, Suman Kumar Vodnala, David B. Thompson…·Denitsa Milanova

The paper identifies tumor-reactive T cells by focusing on productive T-cell engagement with tumor cells, showing that such interactions enrich for neoantigen-reactive clonotypes with progenitor-like states.

DOI 10.64898/2026.05.31.729129

humanbulk RNA-seq

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ImmunologybioRxivPreprintMay 11, 2025

Rapid enrichment of progenitor exhausted neoantigen-specific CD8 T cells from peripheral blood

Mamduh Khateb, Raina Jung, Stav Leibou…·Nicholas D. Klemen

This paper describes a method to rapidly enrich neoantigen-specific CD8 T cells from peripheral blood, achieving frequencies comparable to tumor-infiltrating lymphocytes over 28 days.

3 citations

humanbulk RNA-seq

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