Isolation of oxygen-dependent nicotine- and pseudooxynicotine-metabolizing enzymes
Tejas A. Navaratna, Javeria Akram, Thea D Pazdernik, AMUDHA RAMACHANDRAN, Pamela Schultz, Mark E. Dulchavsky, Xavier Choussat, Claire Oczon, Aashnaa Singh, Nikhil Myers, Aaron M. Robida, Ashootosh Tripathi, Frederick W. Stull, James C.A. Bardwell
This paper identifies two oxygen-dependent nicotine and pseudooxynicotine metabolizing enzymes with higher catalytic efficiency than NicA2, suggesting their potential for therapeutic and biotechnological applications.
bioRxiv · Aug 28, 2026 · PreprintBiochemistry