Astrocytic chordin-like 1 (Chrdl1) is re-engaged early after ischemic stroke to regulate region-dependent GluA2 levels and neuronal vulnerability
Bridget R. Boyle, Reina Hastings, Aayushi Patel, Amy J. Gleichman, Stanley Thomas Carmichael, Elena Blanco‐Suárez
This study identifies Chrdl1's role in regulating neuronal vulnerability after ischemic stroke by stabilizing GluA2 and limiting apoptosis, with region-dependent effects.
bioRxiv · Aug 23, 2026 · PreprintNeuroscience