NeurosciencebioRxivPreprint
Impaired cholinergic modulation of striatal spiny projection neurons in repetitive behaviors associated with TSHZ3-linked autism spectrum disorder
Juliette Graniou, Xavier Caubit, Ahmed Fatmi…·Paolo Gubellini
This study shows that TSHZ3 deletion in cholinergic neurons impairs striatal cholinergic modulation, leading to repetitive behaviors in ASD, and that donepezil treatment reduces these behaviors.
DOI 10.64898/2026.11.12.766099