Exploitation of CD3ζ to enhance TCR expression levels and antigen-specific T cell function
Abdullah Degirmencay, Sharyn Thomas, Angelika Holler, Samuel Burgess, Emma C. Morris, Hans J. Stauss
This study shows that CD3ζ enhances TCR surface expression and function in human T cells by increasing endogenous TCRβ expression and reducing mispairing with endogenous chains.
Frontiers in Immunology · May 30, 2024Peer-reviewedImmunology