Pathway-Specific Polygenic Scores for Predicting Clinical Lithium Treatment Response in Patients with Bipolar Disorder
Nigussie Tadesse Sharew, Scott Richard Clark, Sergi Papiol, Urs Heilbronner, Franziska Degenhardt, Janice M. Fullerton, Liping Hou, Tatyana Shekhtman, Mazda Adli, Nirmala Akula, Kazufumi Akiyama, Raffaella Ardau, Bárbara Arias, Roland Hasler, Hélène Richard-Lepouriel, , Layla Kassem
The paper develops pathway-specific polygenic scores to predict lithium treatment response in bipolar disorder and finds associations with specific biological pathways.
Biological Psychiatry Global Open Science · Jun 25, 2025Peer-reviewedGenetic & Genomic Medicine