Liping Hou

This study uses machine learning to model proteogenomic data and identifies plasma biomarkers for early lung cancer detection, achieving AUCs of 0.78-0.88 in predicting diagnosis up to 9 years before symptoms.

The paper develops pathway-specific polygenic scores to predict lithium treatment response in bipolar disorder and finds associations with specific biological pathways.

The paper maps genetic associations with plasma proteins in 54,306 UK Biobank participants, identifying 10,248 new protein quantitative trait loci (pQTLs) and expanding the genetic architecture of the plasma proteome.

The paper shows that polygenic scores for depression traits predict lithium response in bipolar disorder patients, with lower genetic load linked to better treatment outcomes.

This study identifies genetic pleiotropy between bipolar disorder and metabolic/endocrine traits in a multigenerational Amish pedigree using imputed WGS and polygenic risk scores.

The paper shows that a genetic variant linked to mental illness reduces TRANK1 expression in neural cells, which is reversed by valproic acid treatment.

This study finds that a higher genetic risk for schizophrenia is linked to poorer lithium response in bipolar disorder patients, suggesting potential for personalized treatment strategies.