Gustavo Turecki

T2 relaxometry for myelin water fraction: an ex vivo brain imaging study

This study validates and compares TSE and GRASE techniques for myelin water imaging in postmortem human brains, showing moderate to strong agreement between the sequences.

Spatiotemporal trajectories of formaldehyde fixation effects on quantitative MRI in postmortem human brains

This study quantifies how formaldehyde fixation affects MRI metrics in postmortem human brains over time and provides a framework to correct for these effects.

Peripheral blood DNA methylation partially reports on immune cell type composition in the frontal brain

The paper investigates how DNA methylation in peripheral blood relates to immune cell type composition in the frontal brain using epigenome-wide association studies and machine learning.

Multi-omics characterization of astrocyte subtypes reveals spatially coordinated astrocyte downregulation in depression

The paper identifies spatially localized astrocytic dysfunction in depression using multi-omics data and shows its role in disease pathology.

Effects of prolonged fixation on vascular biomarkers in postmortem human brains

This study examines how prolonged formalin fixation affects immunohistochemical and histochemical stains in postmortem human brains, finding decreased staining for specific markers over time.

A comprehensive characterization of the phospholipid and cholesterol composition of the uncinate fasciculus in the human brain: evidence of age-related alterations

This study characterizes the lipid composition of the human uncinate fasciculus and finds age-related changes but no significant differences related to depression or childhood abuse.

A multimodal characterization of the human uncinate fasciculus

This study characterizes the human uncinate fasciculus using multimodal approaches, finding no group differences in histology but identifying differentially expressed genes and age-related changes.

Serotonergic neurons in the dorsal raphe nucleus scale O2 utilization in response to traumatic stress

The paper shows that serotonergic neurons in the dorsal raphe nucleus adjust oxygen utilization in response to traumatic stress, with distinct patterns linked to susceptibility or resilience.

A glucocorticoid-responsive polygenic signature in the anterior cingulate cortex moderates the association of early-life adversity and vulnerability for depression

The paper identifies a glucocorticoid-responsive gene network in the anterior cingulate cortex that moderates the link between early-life adversity and depression risk in adult females.

Pervasive neurovascular dysfunction in the ventromedial prefrontal cortex of female depressed suicides with a history of childhood abuse

This study identifies widespread gene expression changes in the neurovascular unit of female depressed suicides with childhood abuse histories, highlighting key regulators like KLF2 and KLF4.

Characterizing neuronal cell bodies in human postmortem cerebral white matter tracts

The paper validates the presence of neuronal cell bodies in human long-range white matter tracts, finding higher densities in the uncinate fasciculus compared to other regions.

Differential Chromatin Architecture and Risk Variants in Deep Layer Excitatory Neurons and Grey Matter Microglia Contribute to Major Depressive Disorder

This study identifies differential chromatin architecture and risk variants in specific brain cell types associated with major depressive disorder.

Characterizing Oligodendrocyte-Lineage Cells and Myelination in the Basolateral Amygdala: Insights from a Novel Methodology in Postmortem Human Brain

This study develops a method to isolate oligodendrocyte-lineage cells from postmortem brain tissue and finds age-related gene expression changes and a correlation between oligodendrocyte density and myelin area in the basolateral amygdala.

Characterization of the suicide attempt-associated chromosome 7 locus

The paper investigates the functional relationship between a suicide attempt-associated SNP on chromosome 7 and gene expression in brain regions, identifying FOXP2 as a key gene involved.

Bmal1 expression is minimal or absent in human and mouse cerebral microglia

The paper investigates BMAL1 expression in human and mouse microglia using multiple methods and finds minimal or absent expression, with epigenetic factors likely suppressing it.

Glucocorticoid receptors mediate reprogramming of astrocytes in depression.

The paper identifies glucocorticoid receptor-mediated astrocyte reprogramming in depression using post-mortem samples and mouse models.

A post-mortem investigation of the locus coeruleus- noradrenergic system in resilience to childhood abuse

The paper investigates how childhood abuse affects the locus coeruleus-noradrenergic system in post-mortem brain samples, finding reduced neuron density and differential gene expression in resilient individuals.

Persistent dopamine-dependent remodeling of the neural transcriptome in response to pregnancy and postpartum

This study identifies dopamine-dependent transcriptional changes in the dorsal hippocampal formation during pregnancy and postpartum, showing how dopamine modulates neural plasticity and behavior.

A multi-omics and cell type-specific characterization of the ventral striatum in human cocaine use disorder

This study characterizes molecular changes in the ventral striatum of individuals with cocaine use disorder using multi-omics and single-cell approaches, identifying perturbations in metabolic pathways and cell-type-specific alterations.

ECLARE: multi-teacher contrastive learning via ensemble distillation for diagonal integration of single-cell multi-omic data

ECLARE integrates unpaired single-cell multi-omic data using multi-teacher contrastive learning, improving cell pairing accuracy and biological structure preservation in depression studies.

Evidence of microglial involvement in the childhood abuse-associated increase in perineuronal nets in the ventromedial prefrontal cortex

The paper investigates how childhood abuse affects microglial markers and perineuronal nets in the ventromedial prefrontal cortex of individuals who died by suicide.

Spatial transcriptomic analysis of adult hippocampal neurogenesis in the human brain

The paper uses spatial transcriptomics and FISH to analyze adult hippocampal neurogenesis in the human dentate gyrus across ages, finding few neural stem cell markers but significant DCX expression with mixed inhibitory and excitatory phenotypes.

Proteomic evidence of depression-associated astrocytic dysfunction in the human male olfactory bulb

This study identifies proteomic changes in the human male olfactory bulb associated with depression, highlighting astrocytic dysfunction and species-specific differences in mouse models.

Human-specific features of cerebellar astrocytes and Purkinje cells: an anatomical comparison with mice and macaques

The paper compares cerebellar astrocytes and Purkinje cells across humans, macaques, and mice, finding species-specific differences in distribution, size, and marker expression.

Transthyretin orchestrates vitamin B12-induced stress resilience

This study identifies Transthyretin as a sex-specific target of vitamin B12 that influences stress resilience through DNA methylation changes in the prefrontal cortex.

Influence of chondroitin sulfate glycan sulfation patterns on histochemical labeling of perineuronal nets- a comparative study of interregional distribution in human and mouse brain

This study examines CS disaccharide sulfation patterns in human and mouse brains, finding regional and species-specific differences and showing ELS does not affect PNN labeling patterns.

Npbwr1 signaling mediates fast antidepressant action

This study identifies Npbwr1 as a key regulator of depressive-like symptoms and shows that its antagonist CYM50769 rapidly alleviates these symptoms in mice.

Transcriptional dissection of symptomatic profiles across the brain of men and women with depression

This study identifies sex-specific gene modules linked to MDD symptom domains in brain regions, revealing distinct transcriptional signatures in males and females.

Universal method for the gentle isolation of intact microvessels from frozen tissue: a multiomic investigation into the neurovasculature

The paper introduces a method to isolate intact microvessels from frozen tissue and uses multi-omics to characterize the neurovascular unit.

Cell type specific transcriptomic differences in depression show similar patterns between males and females but implicate distinct cell types and genes