Ectopic expression of the sensor CovS cytosolic domain confers phosphatase activity and full virulence to the M1T1 CovSY39H attenuated variant of group A Streptococcus
Abhinay Sharma, Aparna Anand, Miriam Ravins, Usha Kantiwal, Emanuel Hanski
This study shows that ectopic expression of the CovS cytosolic domain restores phosphatase activity and virulence to an attenuated GAS variant, demonstrating the critical role of CovS phosphatase in virulence regulation.
bioRxiv · Jul 30, 2025 · PreprintMicrobiology