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Abhishek K Jha

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Systems Biology· 1

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Approach:benchmark study· 1 Research Focus:benchmarking· 1 Assay:bulk RNA-seq· 1 Research Focus:perturbation response prediction· 1

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Gaurang MahajaniD· 1 shared Kanupriya TiwariiD· 1 shared Nobal Kishor Dhruw· 1 shared Renuka Prakash Bellad· 1 shared

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2026-2026 · peak 1/yr

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Gaurang MahajanORCID

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Systems BiologybioRxivPreprintOct 19, 2026

Genetic Perturbation Prediction Models Fail Out-of-Distribution: A Rigorous Benchmark and Systematic Evaluation

Kanupriya Tiwari, Gaurang Mahajan, Renuka Prakash Bellad…·Abhishek K Jha

This paper evaluates perturbation prediction models under out-of-distribution conditions and finds they perform poorly, highlighting the need for better generalization.

DOI 10.64898/2026.10.16.759604

bulk RNA-seqbenchmark study

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