Genetic Perturbation Prediction Models Fail Out-of-Distribution: A Rigorous Benchmark and Systematic Evaluation
Kanupriya Tiwari, Gaurang Mahajan, Renuka Prakash Bellad, Nobal Kishor Dhruw, Abhishek K Jha
This paper evaluates perturbation prediction models under out-of-distribution conditions and finds they perform poorly, highlighting the need for better generalization.
bioRxiv · Oct 19, 2026 · PreprintSystems Biology