Cell BiologybioRxivPreprint
Loss of Progranulin Results in Increased Pan-Cathepsin Activity and Reduced LAMP1 Lysosomal Protein
Abigail Anderson, Malú G. Tansey
This study shows that loss of PGRN increases pan-cathepsin activity and reduces LAMP1 expression in MEFs, suggesting a role for PGRN in lysosomal function and inflammation.
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