Understanding the Role of Pyruvate Dehydrogenase in Listeria monocytogenes Virulence
Matthew J. Freeman, Noah J. Eral, Abigail M. Debrine, David M. Stevenson, Daniel Amador‐Noguez, John‐Demian Sauer
This study identifies PDH complex defects in L. monocytogenes as critical for intracellular survival, showing that PDH mutants fail to utilize PTS-dependent carbon sources, leading to reduced virulence.
Infection and Immunity · May 29, 2026Peer-reviewedMicrobiology