Sodium Butyrate Rescues Neurodevelopmental Deficits Following Perinatal Methadone Exposure
Isobel A. R. Williams, Josie M. van Dorst, Sarah‐Jane Leigh, Sarah Jane Baracz, B. L. D. Uthpala Pushpakumara, Abigail Marcus, Delyse McCaffrey, Adam K. Walker, Chee Yee Ooi, Meredith C. Ward, Ju Lee Oei, Kelly J. Clemens
This study shows that sodium butyrate reduces neurodevelopmental deficits in rats exposed to methadone prenatally by improving gut-brain axis function and myelination.
bioRxiv · Jun 26, 2025 · PreprintAnimal Behavior & Cognition