Human CYP2C9 metabolism of organophosphorus pesticides and nerve agent surrogates
Pratik Shriwas, Abigail Noonchester, Andre Revnew, Thomas R. Lane, Christopher M. Hadad, Sean Ekins, Craig A. McElroy
This study investigates how CYP2C9 metabolizes organophosphorus pesticides and nerve agents, finding that it preferentially metabolizes thions over oxons and that binding energy correlates with metabolism and inhibition.
Journal of Xenobiotics · Dec 19, 2025Peer-reviewedPharmacology & Toxicology