Pratik Shriwas

This study investigates CYP1A2's role in metabolizing organophosphorus compounds and finds it selectively degrades thions and is inhibited by OP compounds, suggesting its potential as a bioscavenger.

This study identifies two pathways by which extracellular ATP affects cancer cells: macropinocytic uptake increasing intracellular ATP and purinergic receptor signaling inducing senescence.

This study evaluates CYP3A4's metabolism of organophosphorus compounds and finds it preferentially metabolizes thions over oxons, with some compounds inhibiting CYP3A4 activity.

This study investigates how CYP2C9 metabolizes organophosphorus pesticides and nerve agents, finding that it preferentially metabolizes thions over oxons and that binding energy correlates with metabolism and inhibition.

This study shows that DRB18, a pan-class I GLUT inhibitor, synergizes with paclitaxel to reduce NSCLC cell proliferation in vitro and tumor growth in vivo.