Adaptive changes of cholinergic projections to the nucleus accumbens bidirectionally mediate cocaine reinforcing effects
Leandro A. A. Aguiar, Lea Royon, Ricardo Bastos-Gonçalves, Tawan T. A. Carvalho, E Teixeira, AC Faria, RM Jungmann, Daniela Vilasboas‐Campos, AV Domingues, C Soares-Cunha, NAP Vasconcelos, L Pinto, SP Fernandez, Jacques Barik, B Coimbra, AJ Rodrigues
This study shows that cocaine-induced changes in cholinergic projections from the LDT to the NAc bidirectionally affect cocaine's reinforcing effects.
bioRxiv · Jun 30, 2025 · PreprintNeuroscience