Signal peptidase complexes set species-specific rules for signal peptide cleavage
Yeonji Chung, Gilberto P. Pereira, Young June Lee, Achille Agnesa, Lisbeth R. Kjølbye, Henrik Nielsen, Gunnar von HEIJNE, Paulo C. T. Souza, Hyun (Joy) Kim
The paper shows that human signal peptides are inefficiently cleaved by yeast SPCs due to differences in SPC-lipid interactions and membrane thinning profiles.
bioRxiv · Sep 24, 2026 · PreprintCell Biology