Modulation of post-traumatic immune response using anti-IL-1 therapy for improved visual outcomes
Lucy P. Evans, Addison W. Woll, Shu Wu, Brittany P. Todd, Nicole Hehr, Adam Hedberg-Buenz, Michael G. Anderson, Elizabeth A. Newell, Polly J. Ferguson, Vinit B. Mahajan, Mathew M. Harper, Alexander G. Bassuk
This study shows that blocking the IL-1 pathway with anakinra reduces retinal inflammation and preserves retinal ganglion cell function and structure after blast-induced TBI in mice.
bioRxiv · Jun 4, 2019 · PreprintNeuroscience