Alexander G. Bassuk

Artificial Intelligence's Contribution to Biomedical Literature Search: Revolutionizing or Complicating?

This study evaluates ChatGPT's utility for biomedical literature search compared to traditional methods, finding limitations in accuracy and consistency but potential with user-support tools.

Neuroprotective Effects of Naltrexone in a Mouse Model of Post-Traumatic Epilepsy

This study shows that naltrexone prevents neuroinflammation and epileptogenesis in a mouse model of post-traumatic epilepsy.

Selective neuroimmune modulation by type I interferon drives neuropathology and neurologic dysfunction following traumatic brain injury

This study shows that type I interferon signaling worsens neuropathology and neurologic dysfunction after traumatic brain injury by modulating neuroimmune responses.

Modulation of post-traumatic immune response using anti-IL-1 therapy for improved visual outcomes

This study shows that blocking the IL-1 pathway with anakinra reduces retinal inflammation and preserves retinal ganglion cell function and structure after blast-induced TBI in mice.

In trans variant calling reveals enrichment for compound heterozygous variants in genes involved in neuronal development and growth.

The paper introduces VarCount for variant calling and identifies enrichment of compound heterozygous variants in epilepsy-related genes using Epi4k and 1000 Genomes data.

Corrigendum and follow-up: Whole genome sequencing of multiple CRISPR-edited mouse lines suggests no excess mutations.

The paper reanalyzes whole-genome sequencing data from CRISPR-edited mouse lines to assess whether unintended mutations are introduced, finding no excess mutations.