Author

Polly J. Ferguson

University of IowaORCID 0000-0002-9901-0334Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 4

Signature Assays, Organisms & Methods

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Organism:mouse· 3 Approach:experimental assay· 2 Approach:statistical model· 2 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1 Research Focus:variant calling· 1 Assay:whole-exome sequencing· 1

Frequent Co-Authors

Alexander G. BassukiD· 4 shared Elizabeth A. NewelliD· 3 shared Vinit B. MahajaniD· 3 shared Brittany P. Todd· 2 shared Thomas Nickl‐JockschatiD· 2 shared Zeru J. PetersoniD· 2 shared Adam Hedberg-Buenz· 1 shared Addison W. Woll· 1 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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4 shared papersNeuroscience

Alexander G. BassukORCID

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4 papers

Recent·Most cited

Neuroprotective Effects of Naltrexone in a Mouse Model of Post-Traumatic Epilepsy

Saul Rodriguez, Shaunik Sharma, Grant Tiarks, Zeru J. Peterson, Kyle Jackson, Daniel R. Thedens, Angela Wong, David Keffala-Gerhard, Vinit B. Mahajan, Polly J. Ferguson, Elizabeth A. Newell, Joseph C. Glykys, Thomas Nickl‐Jockschat, Alexander G. Bassuk

This study shows that naltrexone prevents neuroinflammation and epileptogenesis in a mouse model of post-traumatic epilepsy.

bioRxiv · Oct 4, 2023 · PreprintNeuroscience

Selective neuroimmune modulation by type I interferon drives neuropathology and neurologic dysfunction following traumatic brain injury

Brittany P. Todd, Zili Luo, Noah Gilkes, Michael S. Chimenti, Zeru J. Peterson, Madison R. Mix, John T. Harty, Thomas Nickl‐Jockschat, Polly J. Ferguson, Alexander G. Bassuk, Elizabeth A. Newell

This study shows that type I interferon signaling worsens neuropathology and neurologic dysfunction after traumatic brain injury by modulating neuroimmune responses.

Acta Neuropathologica Communications · Aug 18, 2023Peer-reviewedNeuroscience

Modulation of post-traumatic immune response using anti-IL-1 therapy for improved visual outcomes

Lucy P. Evans, Addison W. Woll, Shu Wu, Brittany P. Todd, Nicole Hehr, Adam Hedberg-Buenz, Michael G. Anderson, Elizabeth A. Newell, Polly J. Ferguson, Vinit B. Mahajan, Mathew M. Harper, Alexander G. Bassuk

This study shows that blocking the IL-1 pathway with anakinra reduces retinal inflammation and preserves retinal ganglion cell function and structure after blast-induced TBI in mice.

bioRxiv · Jun 4, 2019 · PreprintNeuroscience

In trans variant calling reveals enrichment for compound heterozygous variants in genes involved in neuronal development and growth.

Allison Cox, Fillan S. Grady, Gabriel Velez, Vinit B. Mahajan, Polly J. Ferguson, Andrew Kitchen, Benjamin W. Darbro, Alexander G. Bassuk

The paper introduces VarCount for variant calling and identifies enrichment of compound heterozygous variants in epilepsy-related genes using Epi4k and 1000 Genomes data.

Genetics Research · Jan 1, 2019Peer-reviewedNeuroscience