Co-targeting KRAS and Exportin1 as an effective therapeutic strategy for KRASG12D mutant pancreatic ductal adenocarcinoma
Husain Yar Khan, Mohammed Najeeb Al Hallak, Amro Aboukameel, Sahar F. Bannoura, Md. Hafiz Uddin, Adeeb A. Aboukameel, Fulya Koksalar Alkan, Ahmet B. Çağlayan, Hilmi Kaan Alkan, Bin Bao, Hugo Jimenez, Allan M. Johansen, Callum T. McGrath, Grayson Barker, Khalil Choucair, , Asfar Sohail Azmi
This paper shows that combining Eltanexor and MRTX1133 improves efficacy in KRASG12D mutant PDAC by overcoming resistance and reducing tumor growth.
bioRxiv · Nov 21, 2025 · PreprintCancer Biology