Structural basis of antiphage defense by an ATPase-associated reverse transcriptase
Jerrin Thomas George, Nathaniel Burman, Royce A. Wilkinson, Senuri de Silva, Quynh McKelvey-Pham, Murat Buyukyoruk, Adelaide Dale, Hannah Landman, Ava B. Graham, Steven Z. DeLuca, Blake Wiedenheft
The paper determines the structure of a type I-A retron and shows how it mediates antiphage defense through DNA degradation and nuclease activation.
bioRxiv · Mar 26, 2025 · PreprintBiochemistry