Serum IgM crosslinks hepatitis B subviral particles into supramolecular immune complexes
Chang Liu, Aditi Dhawan, Xinyi Yao, Juyeon Park, Gautam Penna, Sean Mulligan, Lexi Beaver Alexandra Beaver, Helen Chen, Flora Donati, Stephan Urban, Ralf F. W. Bartenschlager, George Georgiou, Shirin Nkongolo, Stefan Seitz, Zunlong Ke
The paper uses cryo-ET to show serum IgM crosslinks HBV SVPs into supramolecular immune complexes through multivalent Fab interactions.
bioRxiv · Oct 2, 2026 · PreprintMolecular Biology