Ralf F. W. Bartenschlager

The paper uses cryo-ET to show serum IgM crosslinks HBV SVPs into supramolecular immune complexes through multivalent Fab interactions.

The paper identifies apolipoprotein C1 as a host factor that facilitates HBV and HDV infection by associating with viral particles and enhancing infectivity through SR-B1.

The paper identifies apoB-containing lipoproteins as a blood-borne innate immune barrier that restricts ZIKV dissemination and congenital infection risk by blocking viral entry through PS receptor competition.

The paper develops a method to isolate intact engineered extracellular vesicles with high purity using twin-Strep tagging and Strep technology, enabling efficient and selective capture and functional delivery of proteins.

This paper identifies covalent cyclic peptide inhibitors targeting protein-protein interactions using phage display, demonstrating antiviral activity against SARS-CoV-2.

The paper expands the known range of nidovirus genomes up to 64 kb and identifies host constraints and new replicase expression modes in giant invertebrate nidoviruses.

This study identifies IL1β as an amplifier of IFN-induced antiviral responses through mathematical modeling and experimental validation.