Quantification of heterogeneity in human CD8+ T cell responses to vaccine antigens: an HLA-guided perspective
Duane C. Harris, Apoorv Shanker, Makaela M. Montoya, Trent R. Llewellyn, Anna R. Matuszak, Aditi Lohar, Jessica Z. Kubicek-Sutherland, Ying Wai Li, Kristen M. Wilding, Benjamin H. McMahon, Sandrasegaram Gnanakaran, Ruy Miguel Ribeiro, Alan S. Perelson, Carmen Molina-Parı́s
The paper introduces metrics to quantify CD8+ T cell responses to vaccine antigens, considering HLA genetic variation and viral evolution, using Ebola, SARS-CoV-2, and Burkholderia pseudomallei as examples.
Frontiers in Immunology · Nov 17, 2024Peer-reviewedImmunology