BiophysicsbioRxivPreprint
Structure-Based Optimization of Pathogen Signal Sequences for Enhanced Antigen Expression in Humans for Vaccine Designs
Hung Nguyen Do, Apoorv Shanker, Ria Q. Kidner…·Sandrasegaram Gnanakaran
This paper introduces a structure-based workflow to optimize signal peptides for enhanced antigen expression in human cells, showing that structurally optimized SPs improve protein secretion for vaccine candidates.
DOI 10.1101/2025.11.25.690495