Author
Los Alamos National LaboratoryORCID 0000-0002-3988-8241Unclaimed ORCID profile · follow to get notified of new preprints
5 papers
Recent·Most cited
Tin Phan, Nicole Pagane, Jasmine A. F. Kreig…·Alan S. Perelson
The paper develops a mechanistic model linking CD8+ T cell expansion sensitivity to HIV post-treatment control, showing strong correlations with Ki-67 and TCF-1 levels.
Tin Phan, Maud Mavigner, Amir Dashti…·Alan S. Perelson
This study quantifies AZD5582's effect on SIV reservoirs in macaques, showing it reactivates 25% of latent cells per dose and clears 60-79% of reactivated cells.
Sarafa A. Iyaniwura, Tyler Cassidy, Ruy Miguel Ribeiro, Alan S. Perelson
The paper develops a multiscale model of CAM treatment in chronic HBV infection, showing HBV RNA is more sensitive to CAM effectiveness than HBV DNA.
Tin Phan, Ruy Miguel Ribeiro, Gregory E. Edelstein…·Alan S. Perelson
The paper models viral rebound after nirmatrelvir-ritonavir treatment, finding that target cell preservation and incomplete viral clearance drive rebound, with extended treatment reducing this risk.
Duane C. Harris, Apoorv Shanker, Makaela M. Montoya…·Carmen Molina-Parı́s
The paper introduces metrics to quantify CD8+ T cell responses to vaccine antigens, considering HLA genetic variation and viral evolution, using Ebola, SARS-CoV-2, and Burkholderia pseudomallei as examples.