A GluN2B disease-associated variant promotes degradation of NMDA receptors via autophagy
Taylor M. Benske, Marnie P Williams, Pei-Pei Zhang, Adrian Palumbo, Ting‐Wei Mu
The paper shows that the R519Q GluN2B variant is degraded via autophagy-lysosomal pathway, providing a mechanism for NMDAR variant clearance and potential therapeutic targets.
Journal of Biological Chemistry · Jan 10, 2026Peer-reviewedCell Biology