Restoration of E-cadherin Expression Alters Metastatic Organotropism in Invasive Lobular Breast Carcinoma Models
Laura Savariau, Nilgun Tasdemir, Insa Thale, Ashuvinee Elangovan, Kai Ding, Dixcy Jaba Sheeba John Mary, Brent Thomas Schlegel, Jennifer M. Atkinson, Jagmohan Hooda, Adrian Vincent Lee, Steffi Oesterreich
This study shows that restoring E-cadherin in ILC models reduces metastasis to specific organs but has limited effects on primary tumor growth and 2D cell growth.
bioRxiv · May 18, 2026 · PreprintCancer Biology