Genomic signatures of past and present chromosomal instability in the evolution of Barretts esophagus to esophageal adenocarcinoma
Matthew D. Stachler, Chunyang Bao, Richard W. Tourdot, Gregory J. Brunette, Chip Stewart, Lili Sun, Hideo Baba, Masayuki Watanabe, Agoston Agoston, Kunal Jajoo, Jon M. Davison, Katie Sue Nason, Gad A. Getz, Kenneth K. Wang, Yu Imamura, , Cheng‐Zhong Zhang
This study identifies genomic signatures of chromosomal instability in Barrett's esophagus progressing to esophageal adenocarcinoma, showing sloping copy-number variation as a precursor to complexity.
bioRxiv · Mar 26, 2021 · PreprintCancer Biology