Author

Lili Sun

Broad Institute

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Same name, identified by ORCID

Biology Disciplines

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Cancer Biology· 1 Developmental Biology· 1 Genetics· 1

Signature Assays, Organisms & Methods

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Organism:human· 2 Approach:statistical model· 2 Assay:whole-genome sequencing· 2 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Organism:mouse· 1

Frequent Co-Authors

Cheng‐Zhong ZhangiD· 2 shared Adam Joel BassiD· 1 shared Agoston Agoston· 1 shared Chip StewartiD· 1 shared Choayang Wang· 1 shared Chunyang BaoiD· 1 shared David S. PellmaniD· 1 shared Gad A. GetziD· 1 shared

Activity by Year

2018-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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2 shared papersGenetics

Cheng‐Zhong ZhangORCID

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Author profile →

3 papers

Recent·Most cited

Chromothripsis as an on-target consequence of CRISPR-Cas9 genome editing

Mitchell L. Leibowitz, Stamatis Papathanasiou, Phillip A. Doerfler, Logan J. Blaine, Lili Sun, Yu Yao, Cheng‐Zhong Zhang, Mitchell J. Weiss, David S. Pellman

This paper shows that CRISPR-Cas9-induced DNA breaks can lead to chromothripsis, a catastrophic chromosomal rearrangement, which is an on-target toxicity in genome editing.

Nature Genetics · Apr 12, 2021Peer-reviewedGenetics

Genomic signatures of past and present chromosomal instability in the evolution of Barretts esophagus to esophageal adenocarcinoma

Matthew D. Stachler, Chunyang Bao, Richard W. Tourdot, Gregory J. Brunette, Chip Stewart, Lili Sun, Hideo Baba, Masayuki Watanabe, Agoston Agoston, Kunal Jajoo, Jon M. Davison, Katie Sue Nason, Gad A. Getz, Kenneth K. Wang, Yu Imamura, , Cheng‐Zhong Zhang

This study identifies genomic signatures of chromosomal instability in Barrett's esophagus progressing to esophageal adenocarcinoma, showing sloping copy-number variation as a precursor to complexity.

bioRxiv · Mar 26, 2021 · PreprintCancer Biology

Dynamic changes in Sox2 spatio-temporal expression direct the second cell fate decision through Fgf4/Fgfr2 signaling in preimplantation mouse embryos

Tapan Kumar Mistri, Wibowo Arindrarto, Wei Ping Ng, Choayang Wang, Leng Hiong Lim, Lili Sun, Ian Chambers, Thorsten Wohland, Paul Robson

The paper quantifies Sox2 and Oct4 synergistic binding to Sox/Oct motifs, showing Sox2 levels drive Fgf4 expression, influencing cell fate decisions in mouse embryos.

Biochemical Journal · Feb 27, 2018Peer-reviewedDevelopmental Biology