Author

Richard W. Tourdot

Broad InstituteORCID 0000-0002-8409-2912Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Organism:human· 3 Approach:statistical model· 3 Research Focus:differential expression· 2 Assay:Hi-C· 2 Assay:whole-genome sequencing· 2 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:gene regulatory network inference· 1 Research Focus:spatial domain detection· 1

Frequent Co-Authors

Cheng-Zhong ZhangiD· 3 shared Gregory J. BrunetteiD· 3 shared Adam Joel BassiD· 1 shared Agoston Agoston· 1 shared Chip StewartiD· 1 shared Chunyang BaoiD· 1 shared Darawalee WangsaiD· 1 shared David S. PellmaniD· 1 shared

Activity by Year

2021-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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3 shared papersGenomics

Cheng-Zhong ZhangORCID

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3 papers

Recent·Most cited

Haplotype-resolved reconstruction and functional interrogation of cancer karyotypes

Gregory J. Brunette, Richard W. Tourdot, Jinyu Wang, Darawalee Wangsa, David S. Pellman, Cheng-Zhong Zhang

This paper introduces refLinker, a method for haplotype-resolved analysis of cancer karyotypes, revealing transcriptional consequences of somatic Xi rearrangements.

Cell Systems · Mar 1, 2026Peer-reviewedGenomics

Determination of complete chromosomal haplotypes by bulk DNA sequencing

Richard W. Tourdot, Gregory J. Brunette, Ricardo A. Pinto, Cheng‐Zhong Zhang

This paper presents a computational method to determine complete chromosomal haplotypes using bulk long-range sequencing and Hi-C data, achieving high precision and completeness in diploid human genomes.

Genome biology · May 6, 2021Peer-reviewedGenomics

Genomic signatures of past and present chromosomal instability in the evolution of Barretts esophagus to esophageal adenocarcinoma

Matthew D. Stachler, Chunyang Bao, Richard W. Tourdot, Gregory J. Brunette, Chip Stewart, Lili Sun, Hideo Baba, Masayuki Watanabe, Agoston Agoston, Kunal Jajoo, Jon M. Davison, Katie Sue Nason, Gad A. Getz, Kenneth K. Wang, Yu Imamura, , Cheng‐Zhong Zhang

This study identifies genomic signatures of chromosomal instability in Barrett's esophagus progressing to esophageal adenocarcinoma, showing sloping copy-number variation as a precursor to complexity.

bioRxiv · Mar 26, 2021 · PreprintCancer Biology