Immunization with Plant-based Vaccine Expressing Toxoplasma gondii SAG1 Fused to Plant HSP90 Elicits Protective Immune Response in Lambs
Lucía María Campero, Ignacio Gual, Valeria Analía Sander, Luisa F. Mendoza Morales, Víctor A. Ramos-Duarte, Paula M. Formigo, Emiliano Sosa, Fermín Lázaro, María Valeria Scioli, Agustín Atela, Ariel Legarralde, F. Hozbor, Germán Cantón, Sergio Oscar Angel, D.P. Moore, Marina Clemente
This study evaluates two vaccines against Toxoplasma gondii in lambs, showing that the recombinant vaccine increases anti-SAG1 IgG and the plant vaccine boosts IFN-γ levels and reduces histopathological lesions.
bioRxiv · Nov 15, 2024 · PreprintMolecular Biology